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Research Study On White Blood Cells May Help Insulin Resistance

Insulin resistance is the precursor to type II diabetes which has risen to epidemic levels in the US. While diet and exercise changes continue to be the best strategies for improving insulin sensitivity, new research may pave the way towards breakthrough treatments.

Scientists have long understood that inflammation in the body is the root problem behind type II diabetes and other chronic disease. The majority of studies are now focused on ways to reduce inflammation and thereby diminish the effects of low insulin sensitivity in the body.

Researchers at the University of of California, San Diego School of Medicine, have found that a certain type of while blood cell (called “neutrophils”), who’s primary role is attacking bacteria and foreign invaders in the body, also plays a role in mediating insulin resistance.

More after the jump…

A recent article in Science Daily News reports on this exciting new research.

Here’s an excerpt from the article:

The findings are published in the August 5, 2012 Advance Online Publication of Nature Medicine.

Neutrophils are the first immune cells to respond to tissue inflammation, and can promote chronic inflammation by summoning other white blood cells called macrophages. Chronic low-grade inflammation, common in adipose or fat tissue, is an important cause of systemic insulin resistance.

Using liver and fat cells from mice and humans and live mouse models, a team led by Jerrold M. Olefsky, MD, associate dean for scientific affairs at UC San Diego Health Sciences and professor of medicine, discovered that an enzyme secreted by neutrophils called neutrophil elastase (NE) impairs insulin signaling and boosts resistance. Conversely, deletion of NE in obese mice fed a high-fat diet improved insulin sensitivity. Go to article.

Granted this is an animal study (research was done on mice), but never-the-less, it’s shows promise for future studies on humans and may open the door to new treatments.

In theory, a drug or treatment that could serve as a neutrophil elastase (NE) inhibitor, could work to reverse or improve insulin resistance.

I’ll keep a look out for further research and news on any developments and when I find anything you’ll be the first to know.

Shane Doll is a certified Charleston personal trainer, fat loss expert, speaker, and founder of Shaping Concepts. With a staff of over 10 certified fitness professionals, Shaping Concepts provides personal fitness training in Charleston with a specialty on weight loss and body transformation. Sign up today for a no obligations consultation.

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Category: News.